Sentence examples for mutations in basic from inspiring English sources

C/EBP α is mutated in ∼9% of AML cases; reported mutations in C/EBP α comprise point mutations in basic leucine-zipper domain or N-terminus frame-shift mutations leading to formation of a dominant negative C/EBP α isoform (30 kDa mutant CCAAT-enhancer-binding protein alpha (p30C/EBP α)) encoded by same CEBPA from different translation start site.

Interestingly, the talin rod binds to the same loop in F3 that is involved in integrin activation, and mutations in basic residues in the loop that interact with a acidic residues in the talin rod 5-helix bundle (Fig. 7B) enhance the ability of full-length talin to promote Mn2+-induced αVβ3-integrin clustering (Saltel et al., 2009).

Since mutations in these basic amino acids are likely to cause electrostatic disturbances, an impairment of the enzyme biological activity by C132 mutation would be expected.

The baboon HBV had mutations in the basic core promoter and precore regions not found in subgenotype A2.

Therefore, we introduced recently published mutations in our basic TNC-TRAIL construct conferring specificity for TRAILR1 (G131R/R149I/S159R/N199R/K201H/S215D) and TRAILR2 (Y189Q/R191K/Q193R/H264R/I266L/D267Q).

Mutations in the basic core promoter (BCP) and its adjacent precore (preC) region in HBV genome are common in chronic hepatitis B patients.

FHB in adults has been associated with mutations in the basic core promotor BCP (1762 A to T and 1764 G to A) [ 1] and the precore region (1896 G to A) [ 2, 3].

We have performed additional EMSA experiments to address (i) if other mutations in the basic cluster behave similarly and (ii) if the DNA binding of full-length MeCP2-R306C impairedred.

We found that mutations in the basic and conserved patches (Mut-1 and Mut-2) prevented PatL1 from interacting with DCP2, EDC4 and the LSm1 7 ring as efficiently as deleting the Mid and Pat-C domains.

The same mutations were created in basic haploid strains 8C-YUNI101 and E134.

While the percentage overlap is substantial, it is evident from this analysis that no single point mutation in a basic PRP gene would generate a classical toxic gliadin epitope.