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Biologically complex diseases such as cancer are caused by mutations in biological pathways or functional groups instead of individual genes.
Such changes are akin to mutations in biological sequences.
Furthermore, a recovery of 90% was obtained when detecting the target sequence in spiked HeLa cells lysate, demonstrating the feasibility of this detection strategy for single-base mutations in biological samples.
We have revised all supplementary files to provide salient annotations to help the reader place mutations in biological context.
When quantum computers are realized, they will execute quantum programs already developed for comparative genomics tasks, including the identification of mutations in biological sequences (Gueltas et al. 2014).
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However, not all the cases harboured mutations in these biological processes, suggesting that other biological alterations (for example, epigenetic modifications, stromal alterations) could contribute to the morphologically specific pattern of IMPCs, knowing that this hypothesis should be further supported by in vitro experiments.
Recent technological advances enabled the development of several more sensitive and rapid methods than direct sequencing for the detection of EGFR mutations in multiple biological samples.
Preliminary evidence is also emerging that suggests tumour susceptibility to ZD6474 may be influenced by mutations in the biological targets within the tumour (EGFR, RET).
The discrepancy between the effects of the R358A and W359A mutations on integrin-binding in vitro versus their effects in the cell illustrates the importance of analysing the effects of such mutations in a biological setting.
Variation: In biological evolution, variation usually takes the form of physiological, anatomical, or behavioral traits and comes about as the result of random mutation.
Internal variation (e.g. natural mutations) is inevitable in biological systems and, consequently, critical functions should be resistant to such perturbations.
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