Sentence examples for mutations in low from inspiring English sources

The spectrum of TP53 mutations in low- and high-grade tumors has been already described [ 21].

We verified a significant association between the mutation frequency and the gastric cancer risk area (p < 0.001: overall identified mutations in low- vs. middle/high-risk areas).

The vast majority of somatic mutations in low- and high-grade foci were private to the focus in which they were identified.

In this study we tried to determine the extent of mutations in low and high grade primary human tumors of astrocytic origin.

That means that unlike typical false negatives, increasing coverage will not help identify mutations in low GMS regions, even with 0% sequencing error.

In a larger study, we have shown that many (but not all) mutations in low frequency genes affect their functional property [ 44].

Knowledge of the genetic abnormalities present in pediatric LGAs is limited, though recent studies have identified BRAF translocations, chromosomal duplications, and occasional base mutations in low-grade astrocytomas[18], [25], as well as diverse mechanisms for activating the ERK/MAPK pathway in pilocytic astrocytomas [23].

Seventy of 7987%7%) high-confidence somatic mutations in low-grade disease were private to low-grade foci.

Mutations in low-penetrance genes may account for a larger proportion (10 to 30%) of all breast cancers [ 5].

Conversely, PCSK9 loss-of-function mutations result in low levels of LDL cholesterol (LDLC) and protect against coronary heart disease.

Four of the evolved clones also lost quickly on low monosaccharide; the remaining clones had approximately the same fitness as the ancestor, suggesting that most of the mutations acquired in low sucrose were selectively neutral in the equivalent monosaccharide concentration.