Sentence examples for mutations in obese from inspiring English sources

Neomorphic agouti mutations in obese yellow mice.

Subsequently Meyre et al. identified further FTO heterozygous, loss-of-function mutations in obese as well as lean subjects, further clouding FTO's causative role [41] and illustrating the complexity of interpreting the function of this dioxygenase in energy balance [42].

Wagner now plans to look for the ICAM-1 mutation in obese people.

In addition Glis3 mutations in non-obese diabetic (NOD) mice have been shown to underlie β-cell fragility and susceptibility to T1D17.

In this study, we aimed to screen the potential mutations in LEP in obese patients with BMI ≥32 kg/m to explore the mechanism of severe obesity in these patients.

Second, studies of naturally occurring loss-of-function mutations in MC4R from obese subjects [23] [27], in conjunction with structure-function studies [28], [29], have identified several key regions of the receptor that are required for binding of the endogenous ligand, α-MSH.

We screened the coding region of SH2B1 for (infrequent) mutations in 95 extremely obese children and adolescents.

PTEN and p27 loss of function mutations are associated with a good prognosis, particularly in obese women.

For example, a tendency of increase or no difference in plasma adiponectin levels was reported in obese mice with a dominant mutation in Nmf15 locus [30], Leptinob/ob mice [31], and a polygenic obese mouse strain NONcNZO5 [32].

The estimated prevalence of mutations causing monogenic forms of obesity ranges from 1 to 5% in severely obese subjects, with mutations in MC4R being most common [2].

Lack of response to leptin is also well described in obese Zucker rats, which bear a mutation (fa) in the leptin receptor gene [ 9].