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Exact(5)

However, in other instances, mutations create a mutant protein ("poison peptide") which interferes with normal function or assumes a new function.

Several mutations create a premature stop codon in the open reading frame and therefore likely represent null alleles (Table 1, Figure 1A).

(2) Can co-existing mutations create a pharmacological obstacle that mediates drug resistance without functionally relieving the cells from addiction?

However, some mutations create a stop codon and hence no protein is encoded, or some mutations do not lead to stable proteins that can be detected by IHC.

Both mutations create a new frame that produces a slightly longer version of LF3 version (supplementary material S5, Supplementary Material online).

Similar(55)

These mutations create an alternate upstream start codon and are predicted to create truncated IRF6 proteins.

The combined mutations created a remodeled SEC3-binding surface and yielded a Vβ domain with an affinity that was increased by 1000-fold (KD = 7 nM).

That is, multiple random mutations supposedly had accumulated before the gene was activated and thus before they could have experienced traditional natural selection, and these mutations created a whole, functioning gene.

In particular, while the two point mutations creating a novel cryptic splice site may be considered to be easily interpreted in terms of their effect on splicing, the small 18 bp deletion within intron 37 is quite peculiar.

If a mutation created a salmonella strain that always opted out of the suicide attacks, these salmonella would benefit in the short term within the gut, but they would have trouble spreading to the next victim.

This mutation creates a new chromosome, sometimes extremely different from its parents, but anyway useful for the renewal of the population.

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