First, we discovered that PIK3CA kinase domain mutations are a frequent event in AR + TNBC clinical cases.
Mutations are a key step in cancer development.
Calebiro, D. et al. Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas.
PINK1 is a mitochondria-targeted kinase, whose mutations are a cause of Parkinson's disease.
Japan's grotesque horror comedies, combining spurting prosthetic gore and computer-generated mutations, are a specialty of the New York Asian Film Festival.
These data suggest that FOXL2 gene mutations are a rare occurrence in isolated POF cases and may not be involved in the pathogenesis of POF.
Ryanodine receptor 1 (RYR1) mutations are a common cause of congenital myopathies associated with both dominant and recessive inheritance in humans.
Cardiologists suspect the problem can arise in several ways, and they'll need to study many more families to find out if TBX20 mutations are a common or rare cause.
But he suspects that the mutations are a laboratory artifact.
Polymeraze I and transcript release factor (PTRF) mutations are a newly recognized disease, which cause congenital generalized lipodystrophy associated with myopathy.
Thus, DNA damages in frequently dividing cells, because they give rise to mutations, are a prominent cause of cancer.
