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Exact(5)
Mutations in Pol β have been linked to various cancers, and these mutations are further correlated with altered Pol β enzymatic activity.
These mutations are further explored in the following analyses.
In addition, small changes in tmRNA function caused by mutations are further amplified by the KanR enzymatic activity.
Recent reports indicate that STAT3 mutations are further associated with reactivation of Epstein-Barr virus and Varicella zoster virus, suggesting that long term control of viruses may require STAT3 [ 8, 9].
Moreover, contrasting biased mutations between the SC and IR regions become evident when the six types of nucleotide mutations are further divided into GC-rich (i.e., A-to-G or C and T-to-G or C) and AT-rich (i.e., G-to-A or T and C-to-A or T) mutations.
Similar(55)
The pathogenicity of the mutations was further corroborated by the high conservation of the mutated amino acids.
Double and triple mutations were further conducted and four mutants H275/293D, H275/310D, H293/310D, and H275/293/310D were obtained.
Plasmids containing the correct mutations were further verified by sequencing.
Transcriptional sequences (cDNA sequences, GQ354123 8) of three accessions with the D7 and D10 mutations were further determined, respectively.
The complexity involved in analysis of activating mutations is further demonstrated by the difficulty in categorizing mutations found in protein databases as deleterious, neutral, or activating.
The stability of the introduced mutations was further checked in viruses recovered from latently infected spleens confirming the retention of the engineered point mutations.
Related(17)
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