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Exact(22)
Deleterious mutations are much easier to study than beneficial mutations.
Transverse mutations are much less frequent than the transition mutations and will affect these equations to a smaller extent.
It is known that EGFR mutations are much more frequent in the Asian population of lung AD and this may influence the association with a given subtype however this result is interesting and worthy of additional investigation.
The phenotypic effects of other types of mutations are much more difficult to predict.
18, 19 In male breast cancer cases, BRCA2 mutations are much more common than BRCA1.
The remaining 48% of the mutations are much more closely spaced than would be expected on a random basis.
Similar(38)
Overall, the prevalence of mutations is much higher in mitochondrial aaRSs, and the two most often mutated aaRSs are mitochondrial glutamyl-tRNA synthetase and dual localized glycyl-tRNA synthetase.
Men with any of these 14 mutations were much more likely than those without to develop an advanced, invasive form of cancer which spread to the lymph nodes or other parts of the body, and to die from the disease.
For most species, the overall rate of harmful mutations was much less than 0.5 per individual per generation, the researchers report in the 13 October issue of Science--too low to justify sexual reproduction.
In the present investigation HRAS mutations dominated over KRAS mutations and HRAS codon 61 mutations were much more frequent than codon 12 mutations, which is in line with most previous investigations.
Deletion mutations were much less often observed, 225 alleles were smaller than their corresponding germline alleles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com