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The potential reasons for lower factor H in renal TMA with lupus nephritis, including autoantibodies against factor H or factor H gene mutations, need further study.
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Why the DAXX-ATRX interface is not susceptible to disease mutations needs further investigation.
However, the functional relevance of these mutations still need further investigations.
However, RNASEL does not account for a significant number of familial prostate cancers in Germany, and the penetrance of deleterious mutations may need further evaluation.
Of note, cases with EMG mutations may need further enhanced therapy such as high dose anthracyclines and regulatory agents for DNA methylation and/or histone modification to improve their clinical outcome.
Also only 75 80% of platform-specific variants were found in the known list of variants (in dbSNP, 1000 Genomes Project or 6500 Exome Sequencing Project), indicating that a significant number of mutations are somatic mutations or sequencing errors that need further investigation.
BARD1 mutations are considered a high cancer risk and need further examination, as their exact function after mutation is relatively unknown.
The findings of molecular marker expressions may need further validations of mutation analysis.
Although several mutation sites in Nav1.8 and Nav1.9 variants were identified, whether these mutations may diversify the function of channels will still need further researches.
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