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However, the L595S mutation was still present.

In deAmTrac-CP and -FP, the T464D mutation was still sufficient to block growth and response.

However, KRAS mutation was still a negative predictor of survival when analysed separately for rectal cancer patients (Table 3).

An exception was I160E, because this particular mutation was still able to dimerize, but autoproteolysis (Fig. 4A) and substrate hydrolysis was reduced (Fig. 4B).

After a few months of ponatinib treatment the T315I mutation was still detected and with the occurrence of another mutation F359C.

We treated these samples with uracil-DNA glycosylase (UDG), sequenced them using the TSACP and then examined if the mutation was still present.

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Similar(51)

Whether any resistance to these Hsp90 inhibitor drugs could arise by Hsp90 mutation is still unknown.

However, its mechanism of leaf-color mutation is still far from fully being understood, and only a few related genes have been cloned up to now.

Although genomic studies in the field of centrosome have been extensively carried out, with the lack of structural conformation, the proteomic analysis of pathological genetic mutation is still a challenging task.

Although this forward genetic approach is powerful (e.g.[14]), identifying the causative mutation is still difficult and time consuming.

Nevertheless the mutation is still obviously different from the wildtype.

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