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The mutation was however identified in two more patients of this family (III:14 and III:8, Figure 1A).
This novel mutation was, however, shown to cause defective receptor shedding, and is associated with reduced levels of sTNFR1 (soluble TNFR1).
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The probability of any individual gene in any cell acquiring a mutation is, however, low.
The calculated effect of the Ile80Phe mutation is however somewhat overestimated compared to experiments.
Mutation is however, not the only neutral process that could explain differences in prokaryotic nucleotide composition.
Human studies including patients with genotype-verified diagnosis of HCM, especially those with a single causative mutation, are, however, few and generally small, as shown by recent studies.
No mutations were however detected in any of the RAF genes.
No PTEN mutations were however detected in the present set of tumors, a finding in line with previous reports of a low PTEN mutation frequency in UC (2%, n = 88) [30], [30].
Inherited germline mutations are, however, rare.
Whether these regions are less likely to reveal de novo mutations is however questionable.
The dGPHR mutations are, however, sublethal and can therefore generate escapers that are smaller than controls.
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