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Other heme peroxidases were less active by orders of magnitude; protein engineering has resulted in impressive improvements but even the most active mutant was still at least an order of magnitude less active than CPO.
When the first 19 residues were deleted, the Sec61β mutant was still able to bundle microtubules with the ER (Fig. 1F).
Attenuation from the vit A2 consensus ERE is not necessarily dependent on DNA binding as the TR alpha DNA binding mutant was still able to inhibit E-dependent transactivation.
In contrast, the Gap1-152K9,16R mutant was still delivered to the vacuolar lumen in proline-grown cells (Fig. 5C).
Therefore, we generated truncated TcdA devoid of the CROPs (TcdA1 1874) and found that this mutant was still cytopathic.
It was found that the homeodomain mutant was still capable of dysregulating a subset of the genes dysregulated by NUP98-HOXD13 [19] indicating that some of the aberrant gene expression is independent of DNA binding by the homeodomain.
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However, the mutant is still susceptible to ponatinib and axitinib [42].
Inactivation of pla severely attenuates Y. pestis during bubonic infection [68], [69]; however, a pla mutant is still lethal during intranasal or intravascular infection [70].
However, this M6P/IGF2R mutant is still capable of restricting anchorage-independent growth of SCC-VII cells.
Thus, although the PfI2W16A mutant is still able to bind to PfPP1, KTISW is a vital and a primary site for the inhibitory activity of PfI2.
However, upon mutation of the FANSHY motif this effect is completely abolished although the receptor mutant is still able to associate with APP in the TEN.
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CEO of Professional Science Editing for Scientists @ prosciediting.com