Sentence examples for mutation to promote from inspiring English sources

Altogether, these data strongly suggest TRIM28 elevation as a new mechanism, other than SPOP mutation, to promote TRIM24 and AR signaling.

This suggests that environment-induced damage or mutation may cooperate with Kras mutation to promote tumor formation.

Such a pattern could result from contemporaneous gene exchange at regional spatial scales (i.e. recombination between sites exceeds the ability of mutation to promote divergence between sites).

Activating PIK3CA p.H1047R mutation has also been shown to cooperate with BRAF p.V600E mutation to promote progression of benign lung tumors to lung cancers [ 38].

Thus it appears again that the requirement for a secondary mutation to promote L-form proliferation will depend on the bacterium tested.

Propagation on quality food was required for either rict-1 or sgk-1 mutation to promote SKN-1 nuclear accumulation and increase oxidative stress resistance (Fig. 1B E, 3B, and Fig. S2D, Supporting information) (Robida-Stubbs et al., 2012), suggesting that signals from the bacterial food source influence SKN-1 at a step downstream of or in parallel to SGK-1 (Fig. 6A).

Here we show that genomic loss of DOK2 is associated with EGFR mutations in human lung adenocarcinoma, and we hypothesized that loss of DOK2 might therefore cooperate with EGFR mutations to promote lung tumorigenesis.

Thus, in the last few years, conditional gene alterations have been used to investigate the ability of specific mutations to promote the development of prostate neoplasia [17], [25] (reviewed in [18]).

Overall, both genetic and epigenetic changes occur during retinoblastoma development and likely cooperate with pRB mutations to promote cancer progression.

These intriguing results indicate several mechanisms by which mutations in checkpoint genes could cooperate with BRCA2 mutations to promote aggressive cell growth.

The normal cells that have lower autophagy capacity are prone to tumorization, and the incipient tumor cells that have higher autophagy capacity possibly are easier to survival in the hash microenvironment and accumulate more mutations to promote malignant progression.