Sentence examples for mutation or epimutation from inspiring English sources

When DNA repair is deficient DNA damages remain in cells at a higher than usual level and these excess damages cause increased frequencies of mutation or epimutation.

Nevertheless, the clinical consequences of the loss of function of these genes, due to mutation or epimutation, are largely unknown.

For genetic counselling of ID families, the knowledge of the nature of the mutation or epimutation subtype is essential to delineate exact risk figures.

Apoptosis-resistant cells might arise in vivo through mutation (or epimutation) and clonally expand through natural selection to form a field of resistant cells (Fig.  1).

In grapevine, somatic variation arises from mutation or epimutation events that first occur in a single cell belonging to a specific cell layer.

On the other hand, in the past several years it became evident that chromosome destabilization, as a result of mutation or epimutation, is likely one of the earliest steps in transforming a normal somatic cell into a cancer cell [ 52, 53].

Like in any other cancer, a series of somatic mutations or epimutations is required for the neoplastic potential to be expressed (Greaves 2000).

Regulatory changes can occur through heritable sequence mutations or epimutations caused by altered patterns of DNA methylation, and there are examples of such mutations in both the coding regions of genes and associated transcription factor-binding regulatory elements that have had an historical impact on plant phenotype.

Indeed, different mutations (or epimutations) in the same gene (CDKN1C) or imprinted region can result in opposite phenotypes.

The presence of MSI and/or certain mutations or epimutations in colorectal tumors provides clinicians with the information needed to choose the appropriate treatment.

The second problem is that it posits upstream mutations (or epimutations) in the hypothesized network with dramatic, widespread effects, but which are not lethal.