Sentence examples for mutation or copy from inspiring English sources

Genes involved in oxidative stress response and squamous differentiation pathways were found to be frequently altered by mutation or copy number alteration or up-/down- regulation in squamous cell lung cancer [27].

Both methodologies are founded on features of classical drivers, which are mainly characterized by significant mutation or copy number patterns.

While FGFR3 mutation or copy number gain is a rare event, studies of these tumors may shed light on how FGFR3 signaling contributes to UC growth and proliferation.

By training cancer gene predictors based on TCGA data, we found that classical cancer drivers are characterized by significant mutation or copy number patterns, but not by altered expression.

Sequencing two candidate genes, ALK and C2orf18, and a single nucleotide polymorphisms array analysis did not reveal a mutation or copy number variation in a patient from the family.

The association of OS and other measured parameters, such as FGFR3 mutation or copy number variation (CNV), was not performed because of limited sample sizes with the presence of these alterations.

These include p53 mutation or copy-number variation of MDM2 and MDM4/ MDMX[ 29].

Gaucher works on developing computational methods of detecting the creation of original proteins from changes in gene sequences and hopes to use a combination of computational, evolutionary, and structural methods to locate sites on genomes where mutations or copy errors may create new proteins.

For instance, while EGFR mutations or copy number alterations are found in nearly 50% of all glioblastomas [1], [2], EGFR inhibition has yet to yield significant improvements in clinical outcome [3].

There were 21 patients whose tumors carried nonsilent mutations or copy number alterations in 17 of these 24 genes.

These alterations, for example, translocations, small deletions or duplications, base pair mutations or copy number variations (CNVs) can be the direct result of an instable genome.