Sentence examples for mutation might promote from inspiring English sources

Alternatively, the R1945Q mutation might promote a conformational change in C-terminal folding that could alter its association with Beclin 1, or result in recruitment of chaperone proteins that would sterically prevent Beclin 1 binding.

Or a mutation might promote cancer 'stemness' by reprogramming a cell that lacked this potential before.

Our data suggest that mitND6 gene nonsense and missense mutation might promote cell migration and invasion in lung adenocarcinoma, probably by NADH dehydrogenase deficiency induced over-production of ROS.

Furthermore, the finding that senescence elicited by acute EPHA3 loss is rescued by loss of p16INK4A (encoded by Cdkn2a) or p53 (encoded by Trp53) suggests that EPHA3 mutation might promote tumorigenesis only in the absence of senescence-inducing pathways (Lahtela et al., 2013).

Given that this mutant cell line, like the others tested here, exhibited no alteration in its ability to form damage-induced Rad51 foci, this raised the possibility that the T3232A mutation might promote the persistence of Rad51 foci after their formation.

Ishigawa et al. have shown that mtDNA missense mutations might promote cell invasion and metastasis in several mice tumor cell lines [ 19].

Increased cytidine deaminase activity in H. pylori-infected gastric tissues promotes the accumulation of various mutations and might promote gastric carcinogenesis.

Increased cytidine deaminase activity in H. pylori-infected gastric tissues appears to promote the accumulation of various mutations and might promote gastric carcinogenesis.

Therefore, it is conceivable that mutations in ADAM33 might promote emphysematous changes, a main phenotype or pathologic change of COPD.

This hypothesis predicts that threonine to alanine mutations at these sites might promote premature phosphorylation by Cak1, and consequently premature activation of Ime2.

Once genetic variance is generated via mutations, temporally fluctuating selection across generations might promote the accumulation and maintenance of genetic variation.