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Variant 5 was associated with reduced levels of the large CXCR1 transcript, suggesting that this mutation might create a more efficient cleavage site and thus reduce the amount of large CXCR1 mRNA.
The mRNAs from the patient carrying variant 5 and the mother with the same mutation contained reduced levels of the CXCR1 large transcript compared to the control, thus confirming the predicted effect of variant 5, suggesting that this mutation might create a more efficient cleavage site and thus reduce the amount of large CXCR1 mRNA (data not shown).
Therefore, a single mutation might create a functional donor splice site.
This principle also applied to sites flanked by an STR on one side and a base in agreement with the motif and phase on the other side (e.g., A in GTGTGTAT), as well as to sites where a mutation might create an STR larger than (period + 1) bp (e.g. T in CAGTAG was counted in P3,5, or A in TAT counted in P1,2).
Similar(56)
Thus, we suggest that SAMHD1 mutations might create a genetic predisposition for stroke that leads to an increased vulnerability to stroke in those patients by interacting with other risk factors.
Nonetheless, it is also plausible that even a synonymous mutation at the mRNA level might create or disrupt an sRNA binding site, thereby altering expression levels and leading to the same differential virulence.
That might create a market for information.
"It might create some mismatches.
What might create some angst?
This might create a hydrophobic seed promoting Huntingtin aggregation.
PIPAC might create synergies with SC.
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