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Thus, this lethal single point mutation might impair myosin-actin basic functions through structural changes in the actomyosin complex.
In dogs, Clark et al., [ 12] described a mutation in intron 10 of the canine SILV gene that was associated with coat color dilution and concluded that the mutation might impair correct splicing of the canine SILV transcript.
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The selected mutations might impair RAL binding while allowing alternative DNA recognition.
We reasoned that these mutations might impair Dpp C-terminal signaling but leave regulation by the EGFR/MAPK or Wg/GSK3 pathways intact.
However, whether mutations might impair the activity of overexpressed HDACs in prostate cancer must be clarified in further studies.
There might be a balance between SSR length and probability of a mutation event, the longer the SSR, the greater the probability it will be "broken" by a point mutation, which might impair further slippage mutation.
As such, the K75A mutation in Tpz1 might impair the stability of the interaction between the Pot1 complex and telomerase.
This type of genetic interaction often indicates a physical association; for example, the missense mutation in smc6-74 mimpairmpair binding to Brc1, which is a defect that might be suppressed by increasing the total cellular concentration of Brc1.
Mutations in PARK2 might impair this function and eventually result in increased cellular toxicity.
Thus, a trf4Δ mutation might indirectly impair germination by alterations in gene expression, including an alteration in histone levels.
We reasoned that the A246T mutation might severely impair the ability of RF2 to recognize all UAA stop codons upon removal of RF1 and thus prevent the RF1 knockout.
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