Sentence examples for mutation might disrupt from inspiring English sources

As the Z3 protein may transport metal-citrate complexes, we speculate that the z3 mutation might disrupt metal ion homeostasis, thus affecting overall growth rate.

This position has previously been associated with disease in other mt-tRNAs (m.1630A>G in mt-tRNAVal [Glatz et al., 2011; Horvath et al., 2009a] and m.5628T>C in mt-tRNAAla [Spagnolo et al., 2001]), and it seems likely that such a mutation might disrupt the secondary structure of the anticodon arm, potentially therefore impacting upon the codon anticodon interaction.

As GxxxG motifs in α-helical domains are known to support helix-helix interactions, it was proposed that such mutations might disrupt cis-dimer formation of CEACAM1.

The mutations were all hydrophobic-to-charged mutations, which might disrupt the folding of the putative CaM-binding helix or its interactions with other helices within this domain, leading to a loss of activity.

If selection is acting to control efficient splicing, it should prevent synonymous mutations that might disrupt the splicing-associated motifs in exons, such as ESEs.

In total we identified 185 pseudogenes (4.3% of the total CDSs) containing frameshift and nonsense mutations that might disrupt expression of functional products [see Additional file 3].

Therefore, we modeled the RIP1 DD structure based on the structure of Fas DD (PDB id 3OQ9) and mapped the mutations that might disrupt the formation of the RIP1 DD/FADD DD complex on the modeled structure of RIP1 DD.

We could not analyze genome sequence of our patient, although a pathogenic mutation of SLCO1B3 might disrupt OATP1B3 protein expression, resulting in the deviation of the ICG test results from other liver function test results.

Mutation of Val40 might disrupt the positioning of the general base by perturbing the packing interactions with the adjacent β-strand, thereby perturbing the packing interactions between Ala114 and the general base.

The new mutations we identified might disrupt (a) polymerization or association/dissociation kinetics, (b) post-translational modifications of A-type lamins or (c) protein protein interactions.

In the absence of information regarding its defined functions or structure it has been difficult to uncover how pathogenic mutations in the protein might disrupt the normal function of seipin and cause disease.