Sentence examples for mutation might impact from inspiring English sources

Mazen et al. did not explicitly hypothesize about how the p.N103K mutation might impact the synthesis, secretion, or biological activity of the protein [18].

As GATA3 protein stability was regulated in a manner similar to ERα, we hypothesized that its stability might also be influenced by estradiol and that the frameshift mutation might impact protein-level regulation of GATA3 by hormone.

DOI: http://dx.doi.org/10.7554/eLife.11315.025 Precedent that the D-loop mutations might impact ATPase activity come from studies of the homodimeric SMC protein Rad50.

These findings suggest that the impairment of PfCRT transport function through the acquisition of resistance mutations might impact the cellular level of amino acids.

Neuronal function places unique demands on Ca2+-handling pathways, and for this reason, fibroblast responses to G protein coupled receptor activation are likely to give only limited insights into how mtDNA mutations might impact on brain function.

The mitochondrial membrane potential is generated by the electron transfer chain (Mitchell and Moyle, 1967), but it is not known how subtle deficits in the electron transfer chain, caused by genetic mutations, might impact on Ca2+ homoeostasis in neurons.

Noting the amino acid differences in mumpsvirus HN, we hypothesized that these mutations might impact not only B-cell epitopes, but also the availability of T-cell epitopes, including those stimulating CD4+ T-helper cells providing memory and enabling a vaccinated individual to recall antibody and cellular immune responses following wild-type virus challenge.

The similarities in clinical phenotype between RS63-3 and RS63-7 and A-T patients led us to consider that mutation of MTPAP might impact the ATM signaling cascade.

These findings suggest that mutations in the 3′UTR might impact the expression of MeCP2 (McGowan and Pang, 2015).

This could be owing to frequent K- ras mutations in CRCs that might impact on the ability of mda-7/IL-24 to induce apoptosis (Bos et al, 1987).

Determining the consequences of mutations in open reading frames that might impact on efficiency of translational initiation or termination would be informative.