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Exact(7)
The mutation is largely restricted to people of Asian descent--and I'm not Asian.
"They were able to escape or avoid human antibody responses," Hensley says, suggesting that this mutation is largely responsible for the poor performance of last year's vaccine.
This suggests CDH1 down-regulation by mutation is largely not associated with EMT.
This point mutation is largely reported in Asian populations and is implied in invasive cervical carcinoma [ 53- 55].
While the former mutation is largely absent from non-European populations, the latter change can be found more or less worldwide.
In both the wild-type and the D12A/D66A backgrounds, the ∼5-fold decrease in dNTP binding affinity caused by the Y254V mutation is largely due to an increase in the dNTP dissociation rate (Table 1).
Similar(53)
The clinical significance of non-codon 600 mutations is largely unknown.
In populations with a small effective size, natural selection is less efficient, and hence, the fate of mutations is largely determined by random genetic drift.
Variation in the rate of frameshift mutations is largely due to variation in the efficiency of mismatch repair across the genome, although the genomic feature responsible for this variation is unknown.
The number of these mutations is largely underestimated because the impact on this finely orchestrated process (2– 4) is hardly predictable, particularly when considering nucleotide variations within exons (5, 6).
We discovered that BAP1 is mutated in about 15% of clear-cell renal-cell carcinoma, and that BAP1 and PBRM1 mutations are largely mutually exclusive.
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