The presence of an EGFR mutation is closely linked to several clinicopathological factors, such as gender, smoking history, and pathological findings.
By contrast, if the il-1 mutation is (closely) linked to either of the other STIII mutations, such F2 should be obtained at a higher frequency.
SCN9A encodes a subunit of the voltage-gated channel Nav1.7, in which a single-gene mutation is closely related to a congenital abnormality in which the sensation of pain is lost [ 6].
The od10 mutation was closely linked to unc-54 (map position +27.4), and was three-factor mapped between SNP pkP1071 (map position +23.4) and SNP pkP1072 (map position +28.48) on the right arm of LGI by crossing marked uev-1 strains to the polymorphic strain CB4856.
Furthermore, ASXL1 mutation was closely associated with mutations of RUNX1, EZH2, IDH, NRAS, JAK2, SETBP1 and SRSF2 in MDS patients.
ASXL1 mutation was closely associated with trisomy 8 and mutations of RUNX1, EZH2, IDH, NRAS, JAK2, SETBP1 and SRSF2, but was negatively associated with SF3B1 mutation.
The NA sequences of those viruses, with the D354G substitution in addition to the H275Y mutation, were closely related to the majority of oseltamivir-resistant viruses isolated in other parts of the world during 2008.
Such a large effect on the equilibrium of this transition is consistent with the H87V mutation being closely connected to the primary site of structural alteration from which the chemical shift differences discussed above appear to be around the Pro Gly linkage.
Previous studies have indicated that several virological factors including HBV-DNA level, HBV e antigen (HBeAg) status, genotype, pre-S internal deletion mutant and basal core promoter (BCP) A1762T/G1764A mutation are closely associated with development of HCC in treatment naïve, chronic hepatitis B patients [ 25].
The alteration (increased G mutations) is closely associated with SHM and/or AID hotspots and causes a G over C strand bias.
Studies across diverse taxa have shown that attenuation of IIS signaling by calorie restriction and IIS-related mutatisns is closely tied to slow aging and extended lifespan, and to improved old-age survival [ 54, 55].
