Sentence examples for abnormality is largely from inspiring English sources

This complex spectrum of progressive ovarian abnormality is largely related to the size of primordial germ cells (PGCs) pool, where prepubertal onset might reflect a complete lack of germ cells since birth causing a failure in the maintenance of ovarian somatic structure and postpubertal onset would reflect a variably insufficient pool of oocytes.

Due to lack of follow-up, the clinical importance of unexpected abnormalities is largely unknown.

The mechanisms underlying these immune functional abnormalities are largely unknown.

This idea has been borne out by the analysis of mice bearing germline deletion of individual ERM proteins, where abnormalities are largely restricted to tissues expressing only one family member.

We employed a second generation inhibitor of mTORC1, everolimus, and found that both cardiac contractile abnormalities and skeletal muscle abnormalities were largely corrected.

Metabolic and innervation abnormalities are largely overlapped and are probably not causally related to myocardial ischemia, suggesting that impaired glucose metabolism is probably neurogenic in nature.

Although some reports describe constitutive changes in MM-BMMSCs, the molecular mechanisms and pathways that induce senescence-associated abnormalities are largely unknown.

However, the biological impact of these abnormalities in renal disease is largely unknown and should be clarified by future studies.

Further, this age group has not been studied extensively and the actual prevalence of ocular abnormalities, transient and permanent, is largely unknown.

Dysregulation of Hmx1 expression is thus a potential causative mechanism in many patients with congenital ear malformations, a common abnormality for which the etiology is largely unknown.

The vast number of structural abnormalities present in cancer genomes is largely attributed to genomic instability, a transient or persistent state that increases the spontaneous mutation rate, leading to gross genetic alterations such as rearrangements and changes in chromosome number (aneuploidy).