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K27M mutation is predominantly found in H3.3, while ∼20%% of K27M mutations are found in H3.1 (Wu et al. 2012; Saratsis et al. 2014).
K-Ras mutation is predominantly observed among Caucasian patients with adenocarcinoma (∼26% vs. 16% among patients with NSCLC of other cell types, and very uncommon among patients with squamous cell carcinoma) and ever-smokers (25% vs. 6% among never-smokers) [17], [18].
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A codon 12 G-to-A mutation was predominantly observed in regular smokers and in heavy smokers (pack-year of smoking > or =36).
Since the E2-211I mutation was predominantly found in the CHIKV strains isolated in central Africa, it is possible that this mutation might give a selective advantage to CHIKV transmitted by Ae. africanus.
28 However, a recent Chinese study on 129 patients with ICP revealed an IVS 3+2T>C mutation in 8.5% of patients and the mutation was predominantly responsible for early-onset ICP (29.4% in early onset vs 1.1% in late onset).
The patients with ASXL1 mutation were predominantly male, older (median, 71 years vs 64 years, P=0.001) and had higher white blood cell counts (P<0.001) and higher IPSS-R score (P=0.002) at diagnosis.
On the other hand, the higher incidence of p53 mutations is predominantly present in left side [ 41– 41].
EGFR and KRAS mutations are predominantly mutually exclusive with very rare tumours containing both genes mutated [ 44, 51].
Mutations were predominantly found in the DNA-binding domain (80.2%, 65/81), with 7.4% (6/81) in the oligomerization domain (Fig. 6a).
All of these mutations are predominantly found in tumors with adenocarcinoma histology.
Although such mutations are predominantly somatic, a family with a germline T790M mutation has also been described [11].
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