Sentence examples for mutation impairs the from inspiring English sources

In these experiments, we observed, for the first time, that the G202A and R346W mutations cause deficient protein stability, and R135C mutation impairs the substrate-induced enzymatic activity, suggesting that impairment of DHODH activity is linked to the Miller syndrome phenotype.

Birthdate labelling at E12.5 and E13.5 showed that the S140G mutation impairs the radial migration of neurons in the SC.

Here we report that the H3 lysine 36-to-methionine (H3K36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentiated sarcoma in vivo.

Apparently, the triple mutation impairs the domain closure thus favoring reprotonation of alternative acceptor sites in coenzyme substrate intermediates by bulk water.

Nevertheless, our data strongly suggest that basonuclin-null mutation impairs the expression of E-cadherin.

These results demonstrate that the RAD50-Q372X mutatimpairsairs the ability of the MRN complex to repair ionizing radiation-induced DNA double strand breaks.

However, S228P had a much larger Trp fluorescence intensity, implying that the mutation impaired the correct quenching of Trp fluorophores in native β/γ-crystallins (Chen et al., 2009; Chen et al., 2006; Kosinski-Collins et al., 2004).

These results indicate that C4 mutation impaired the viral DNA accumulation in newly emerged leaves in plants.

Thus, the spectroscopic experiments indicated that the p.Trp43Arg mutation impaired the wild-type structure of γD-crystallin in solution.

The mms4-7A mutatimpairedired the late processing of SCJs to an intermediate extent compared to Mms4 depletion.

A comparison of the biophysical properties of the recombinant β-crystallins revealed that the mutation impaired the structures of both βB1-crystallin homomer and βB1/βA3-crystallin heteromer.