Sentence examples for mutation hinders the from inspiring English sources

The analysis of molecular dynamics trajectory presented in this paper supports the notion that the p.Cys169Tyr mutation hinders the docking of Cx26 hemichannels by altering protein structure in the extracellular domain.

[Although Figure 6 is not of the NP4(L133V) mutant, it does show the close contact between L130 and the NO.] Nonetheless, the mutation hinders the "closed loop" conformation, which is the likely cause for the loss of dimer formation.

This work became the foundation for his widely recognized studies of how genetic mutations hinder the mitochondrion's effectiveness and may result in a cell's decline and aging.

The trap mutations hinder the escape of He atoms, resulting in their accumulation.

Theoretical and population genetics data predict that in large populations strong constraints act against slightly deleterious mutations, hindering the subsequent fixation of compensatory mutations, and consequently the probability of sub-functionalisation is lower than that of neo-functionalisation [ 42].

One explanation for this observation is that the mutation hinders a full productive interaction with PA within the membrane and is therefore captured and the interaction with Mdm35 is less efficient (Fig 3E).

This mutation sterically hinders the sequential dimerisation and subsequent activation of the PRLR, but notably reduces the PRLR binding affinity 10-fold.

In one German family with PD, the mutation Ile93Met hinders the catalytic activity of UCH-L1, thus causing irregularity in the UPS and allowing protein accumulation (Leroy et al., 1998).

This prevents the analysis of homozygous mutations and hinders the functional analysis of their role(s) in specific cell types such as microspores.

Occurrence of the mutation hindered DNA damage-induced activation of p53 and thus may contribute to the increased resistance to DNA damage in transformed cells.

Further work will address mutation co-reference resolution; In journal papers, very often the authors use pronominal or nominal mutation references that hinders the grounding of impacts.