Sentence examples for mutant impairs the from inspiring English sources

The toxicity of the protein was dependent on the ATPase activity, as overexpression of the ATPase point mutant of Fun30 did not affect cell growth, suggesting that the point mutation in the ATPase mutant impairs the activity of the protein (Figure 9C).

The mib mutant impairs the notch pathway by impacting on ubiquitination of endocytosed notch ligands so perhaps this is "upstream" of the dependence of notch cleavage steps on AKT, but the fact that angptl1/2 over expression rescues the mob phenotype is not further explained or put in context in the Discussion.

Instead the presence of the mutant impairs the DNA-binding of active WT-STAT3 probably as a result of heterodimer formation between WT-STAT3 and STAT3-YF.

As expected, infection with GP1V mutant impaired the ability of the donor SP P14-CD8+ toymocytes to produce TNF.

Surprisingly, overexpression of wild-type Rab35 or its dominant-active mutant impaired the membrane tubule association of MICAL-L1.

Whereas the deletion of the cuf1 +-encoded copper-dependent transcription factor (cuf1Δ mutant) impaired the induction of ctr4 +, transcriptional activation of mfc1 + was unaffected.

In a related study, the C. jejuni pglE mutant impaired the invasion of intestinal epithelial cells and colonization of intestinal tracts in mice.

Perturbation of miRNA function in the eye of conditional Dicer mouse mutants impairs the normal development of the retina, lens, cornea and optic chiasm [ 19- 22].

Applying PERL scripts, we identified the number of mutants impairing the same pathway.

We also showed that the FANCM-MM1 mutant impaired in the interaction with the FA core complex is not defective in suppressing Flex1-induced mitotic recombination, which is consistent with the observation that the FA core complex is not required for maintaining Flex1 stability.

ALS-associated mutant FUS also interferes with SG assembly and morphology, suggesting that mutant FUS impairs the stress response.