Sentence examples for mutation as observed from inspiring English sources

A six fold higher amount of activated Mep2 was required as compared to the wild type to overcome the defects of Gpa2 mutation as observed with the dominant allele of MEP2 [20].

In addition, F128 moves toward the cavity generated by the M61 to alanine mutation, as observed in the M61A single mutant.

Furthermore, we confirmed the higher incidence of contralateral breast cancer in breast cancer patients carrying the CHEK2 1100delC mutation, as observed in earlier studies (de Bock et al, 2004; Schmidt et al, 2007; Weischer et al, 2012).

SNB-1::VENUS was still mislocalized in the nonpresynaptic region of RIA in the ppk-1 overexpression strain with ttx-7 (nj50 ) mutation, as observed in ttx-7 (nj50 ) single-mutant animals.

To investigate if the FARS2 mutation in the patient cells was responsible for compromised mt-tRNA aminoacylation efficiency, we assessed in vitro aminoacylation activity of a recombinant FARS2 protein engineered to carry the identical p.Asp325Tyr missense mutation as observed in our patient.

Wu-Kabat protein variability index showed 13 unique mutations as observed from the protruded peaks' positioned along with the amino acid residue of VP28 protein.

Single point mutations, as observed for HPRT gene transcripts, were present in both tumour and healthy tissues.

While short palindromes and IRs are usually much more stable; they can be associated with the breakpoints of deletion mutations as observed in E. coli [28], [29] and in mammalian cells [30].

SHP2 mutations as observed in hematological malignancies and some solid tumors disrupt this interaction, thereby constitutively activating the phosphatase [ 85, 141].

One possibility is that in highly conserved proteins the occurrence of double mutations, as observed in recessive disease genes, is often associated with lethality, in which case a disease condition will not be observed.

Accordingly, inactivation of the transcriptional activity of p53 by mutations –as observed in SW480 cells– should result in increased β-catenin mRNA and protein levels and transcriptional activity as well as increased mRNA and protein levels of TCF4 (TCF4L2).