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Exact(5)
This indicates that the control ODN does not induce repair of the point mutation, as expected.
The four affected patients were found to be homozygous carriers of this mutation, as expected.
Silent mutations in any other gene co-occurred with a KRAS mutation as expected based on their respective frequencies.
Three of the 5 serrated lesions harboured a BRAF V600E mutation (as expected), but none exhibited epigenetic silencing of MLH1 (Supporting Information Table 1).
A cluster, enriched in genes involved in angiogenesis (VEGFA, TEK, FLT1/3, CDH5, and PECAM1) was overall overexpressed in samples without KIT exon 11 mutation as expected (Imamura et al, 2007).
Similar(55)
The observed high frequencies of FGFR3, TP53, and PIK3CA mutations were as expected.
Given the sequences of the seven targets, the distribution of mutations was as expected.
Results of the TP53 mutation analysis were as expected from data in the scientific literature; however, the absence of KLF6 miscoding mutations in our patients and in the three human prostate cancer cell lines was unexpected.
(9)– (14, 14) The majority of variants identified were transitions leading to nonsynonymous mutations (Fig. 2b,c), as expected.
As shown in Table 1 and Figure 3C, while the VH genes amplified from CD19+CD27−IgD+ cells in the control group had a low number of mutations, as expected (average 3 mutations per gene; mutated in 1.2% bp sequenced), the VH genes from patient CD19+CD27−IgD+ cells had a significantly higher number of mutations (20 mutations per gene, P<0.001; mutated in 6.3% bp sequenced).
No transamidating activity was detected with the W241A and C277S mutations as expected (Fig. 3a).
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