Sentence examples for mutation and accumulation from inspiring English sources

Some studies have shown that TP53 gene mutation and accumulation of the p53 protein are closely related with the presence of serum anti-p53 antibodies [ 5].

Some studies have shown that TP53 gene mutation and accumulation of the p53 protein are closely related with serum anti-p53 antibody positivity.

These results imply that caspase-mediated cleavage of GFAP correlates with elevated GFAP in the context of GFAP mutation and accumulation.

Alexander disease presents clinically as a classical early childhood leucodystrophy with seizure, myelin loss and neuronal degeneration, but is caused by mutation and accumulation of GFAP (glial fibrillary acidic protein).

Given that mutation and accumulation, as detected by IHC, may be telling us different things (Bazan et al, 2002), it would be sensible if future studies combined both methods of assessment.

In the case of the classic tumor suppressor gene p53, mutation and accumulation of p53 leads to the development of cancer as well as autoantibodies to p53, which is considered a result of broken immunological tolerance due in part to mutated p53 [ 31].

Oncocytomas are predominantly benign neoplasms possessing pathogenic mitochondrial mutations and accumulation of respiration-defective mitochondria, characteristics of unknown significance.

Further events that precede cardiomyocyte hypertrophy include myocyte disarray, consisting in an asymmetric distribution of the hypertrophic cardiomyocytes within the ventricle, and interstitial fibrosis, mainly due to an increased synthesis of collagen as a consequence of sarcomere mutations and accumulation of fibroblasts after cardiomyocyte death [ 3, 37, 38].

Changes in mitochondrial genes can happen only by mutation, and the accumulation of such mutations can be used to trace ancestries.

Moon, D. C. et al. Emergence of a new mutation and its accumulation in the topoisomerase IV gene confers high levels of resistance to fluoroquinolones in Escherichia coli isolates.

In addition, few tumours were characterised for H3.3 mutation and TP53 accumulation.