This study was designed to investigate a possible involvement of CSF fibrinogen in MS pathogenesis during times of acute inflammation, since vascular abnormalities and accumulation of perivascular fibrin are key findings in MS [ 8].
Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the Philadelphia chromosome as the sole genetic abnormality and the accumulation of mature cells in peripheral blood into blast crisis, which is characterized by the rapid expansion of myeloid- or lymphoid-differentiation-arrested blast cells.
These microtubule, actin cytoskeletal and molecular motor defects are early pathogenic events in our AD model and might lead to transport abnormalities and the accumulation of organelles (synaptic vesicles, autophagosomes, mitochondria, lysosomes) within axonal neurites promoting the dystrophic process.
These alterations included nuclear abnormalities, progerin expression and accumulation, altered DNA repair mechanisms and premature senescence (Liu et al., 2011; Zhang et al., 2011).
The cataract may have been observed during childhood, but lens opacity may have increased in severity with aging and accumulation of metabolic abnormalities, since no abnormalities were observed in other pathways.
Gastric cancer (GC) develops through deregulation of gene expression and accumulation of epigenetic abnormalities, leading to tumor cell acquisition of malignant features.
Using a transgenic model targeting the murine gene, Davies et al. [ 41] demonstrated striking cardiac manifestations, such as hypertrophy, impaired contractile function, electrical conduction abnormalities and marked glycogen accumulation.
Interestingly, CD36 deletion rescues the cardiac dysfunction, metabolic abnormalities and myocardial triacylglycerol accumulation observed in transgenic mice with cardiac-restricted PPARα overexpression [ 7], suggesting a critical role for CD36 in the development of diabetes-related heart disease [ 12].
It involves slow proliferation and accumulation of incompetent B-lymphocytes and concurrent abnormalities in both humoral and cellular immunity.
They distinguish six key features of the disease, among them: asthma, peripheral blood eosinophilia of >10 %, mono- or polyneuropathy, paranasal sinus abnormality, eosinophilic accumulation in tissues confirmed by a biopsy, and migratory infiltrates in lungs.
