Sentence examples for mutation accumulation rate from inspiring English sources

These gene losses are expected to increase the mutation accumulation rate.

The 13-fold elevated mutation accumulation rate in xpa-1 compared to 7-fold in nth-1 [ 9], supports this possibility.

Another assumption of Peto's paradox, based on the fact that the rate of malignant transformation may be constant and similar across cell types, is that the mutation accumulation rate is constant among the cells.

This higher mutation accumulation rate, together with the much shorter length of strain-specific genes in S. atrichopogonis (average = 265 bp; Q1/Q2/Q3 = 162/228/327 bp) compared with S. eriocheiris (average = 830 bp; Q1/Q2/Q3 = 329/663/1,063 bp), suggests that a large proportion of these S. atrichopogonis-specific genes may be fragments of unrecognizable pseudogenes.

Mutation accumulation in the Tier 3 genome can be used as a marker for overall mutation accumulation rates.

Since we were unable to define a common set of mutation parameters that would recapitulate the experimentally observed mutation accumulation rates, somatic evolution/leukemia incidence, and HSC fitness decline with age, we tested an alternative, evolutionary model.

We provided a ranking system based on the mutation accumulation rates for prioritizing exome-captured human genes, and propose that clinical reports associating any disease/phenotype to FLAGS be evaluated with extra caution.

Notably, the slope of DNA methylation accumulation in a set of CpG sites in blood cells ([ 19]; 95% CI: 0.061-0.062; Fig. 4B) is well within the CI for Tier 3 mutations (Fig. S2), indicating that mutation accumulation rates for genetic and epigenetic changes may be similar (both being consistent with cell division kinetics; Fig. 3A).

Because the mutational target used by Wielgoss et al. (2011) is likely to experience purifying selection during 40,000 generations, it would be appropriate to accept the E. coli specific-locus rate as the best current measure, and to estimate the average selection coefficient against synonymous base substitutions from the 6-fold lower mutation-accumulation rate.

In this case, acquiring a mutator phenotype, which still accelerates the rate of driver gene mutation accumulation, does little to accelerate the rate of clone growth, and so selection for mutator cells is weak.

To assess the net effect of HGT on Muller's ratchet, we measured the rate of mutation accumulation Δ mfix /Δ t as a function of r (HGT rate) for different combinations of N and s n ¯ m LLC values.