mutation accumulation hypothesis

USAGE SUMMARY

The phrase "mutation accumulation hypothesis" is correct and usable in written English.
It can be used in discussions related to evolutionary biology, genetics, or theories about the accumulation of mutations over time in organisms. Example: "The mutation accumulation hypothesis suggests that the accumulation of deleterious mutations can lead to aging and decreased fitness in populations."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

5 human-written examples

One biological observation regarded as crucial support for the mutation accumulation hypothesis are the Virginia opossum.

Bioinformatics and Biology Insights

Thus simulations predicted some observations, and these observations do not contradict the mutation accumulation hypothesis in the Penna implementation.

Bioinformatics and Biology Insights

Our observation that five out of eight regions with significant effects on longevity are in regions of suppressed recombination, which are much more likely to harbor unconditionally deleterious alleles of large effect with elevated minor allele frequencies than regions of normal recombination, lends support to the mutation accumulation hypothesis for variation in longevity.

Genome Biology and Evolution

Stouthamer et al [ 37] posed the "neutral mutation accumulation" hypothesis: once a PI- Wolbachia infection had reached fixation there would be no more selection to maintain alleles involved in sexual reproduction and over time both male and female sexual function would erode.

BMC Evolutionary Biology

This argument is not restricted to humans and indeed the Gompertz law also applies to many animals (Vaupel et al. 1998), with different time scales for the slope b and the characteristic age X. Penna implemented this mutation accumulation hypothesis by dividing life into 32 time intervals and by representing the genome (DNA) through a string of 32 bits, each of which can be zero or one.

Bioinformatics and Biology Insights

Human-verified similar examples from authoritative sources

Similar Expressions

55 human-written examples

The fact that they are all mutators, however, is consistent with the hypothesis that mutation accumulation drove the observed phenotypic changes.

BMC Evolutionary Biology

Further tests of the hypothesis of mutation accumulation might more fruitfully focus on diseases 1) epidemiologically characterized by a very late and/or less variable age of onset and/or 2) with an abundance of common and ancient alleles.

Plosone

Initially we expect the "costly female traits" mutations to spread through their selective advantage, while other genes involved with sexual behavior in females and all male-specific traits should accumulate mutations at a neutral rate ("neutral accumulation hypothesis").

BMC Evolutionary Biology

The theory underlying the mutation accumulation assay is that all mutations other than lethal mutations accumulate as if neutral.

G3: Genes, Genomes, Genetics

Moreover, the results presented here show that both duplications and deletions are larger in the adaptive recovery populations than in mutation accumulation lines, which is not predicted by the transmission bias hypothesis.

BMC Genomics

Two main classes of hypotheses have been proposed to explain its advantage: detrimental mutation clearance and beneficial mutation accumulation.

BMC Evolutionary Biology

Expert writing Tips

Best practice

When discussing the "mutation accumulation hypothesis", clearly define the context, such as the specific organism or trait being studied, to enhance clarity and avoid ambiguity.

Common error

Avoid implying direct causation solely based on observed correlations between mutation accumulation and phenotypic changes; further experimental evidence is needed to establish causality.

Linguistic Context

The phrase "mutation accumulation hypothesis" functions as a noun phrase identifying a specific scientific theory. As Ludwig AI confirms, it's grammatically sound and used in scientific discourse.

Expression frequency: Rare

Frequent in

Science

100%

Less common in

News & Media

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Formal & Business

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Academia

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Ludwig's WRAP-UP

The phrase "mutation accumulation hypothesis" is a grammatically sound and scientifically recognized term used to describe a theory related to the accumulation of mutations, as Ludwig AI confirms. It is primarily employed in formal and scientific contexts, predominantly within research papers and academic discussions. While its frequency is relatively rare, the term serves as a precise and established way to reference this specific evolutionary concept. To ensure clarity, it's beneficial to specify the context in which the hypothesis is being discussed. When writing or speaking about it, avoid confusing correlation with causation by ensuring claims are properly supported with experimental evidence.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

Mutation accumulation theory

Replaces "hypothesis" with "theory", suggesting a more established or widely accepted viewpoint.

Hypothesis of mutation accumulation

Reorders the words while retaining the original meaning.

Accumulation of mutations hypothesis

Focuses on the "accumulation of mutations" as the core concept.

The mutational accumulation hypothesis

Adds "mutational" to specify the type of accumulation.

Genetic degradation hypothesis

Highlights the consequence of mutation accumulation, which is genetic degradation.

Deleterious mutation accumulation hypothesis

Specifies that the accumulated mutations are harmful or detrimental.

The theory of accumulating mutations

Presents a more general description of the concept as a theory.

Mutation load hypothesis

Refers to the burden of mutations within a population.

The hypothesis regarding the buildup of mutations

Emphasizes the 'buildup' process using different wording.

The concept of mutational burden

Focuses on the overall impact of mutations on an organism or population.

FAQs

What does the "mutation accumulation hypothesis" propose?

The "mutation accumulation hypothesis" suggests that deleterious mutations accumulate over time, especially when natural selection is weak, potentially leading to aging or reduced fitness.

How can I use the term "mutation accumulation hypothesis" in a sentence?

Example: "The "mutation accumulation hypothesis" predicts that organisms with small population sizes will experience a faster rate of decline due to the buildup of harmful mutations."

What are some alternative phrases to "mutation accumulation hypothesis"?

You can use alternatives like "mutation accumulation theory" or "hypothesis of mutation accumulation", which convey a similar meaning.

How does the "mutation accumulation hypothesis" relate to aging?

The "mutation accumulation hypothesis" is one explanation for aging, suggesting that the accumulation of deleterious mutations over time contributes to the decline in physiological function associated with aging.