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More recently, Pannebakker et al. (2008) performed a mutation accumulation study, demonstrating that sex ratio has a mutational heritability of 0.001 0.002.
Montville et al. (2005) subsequently used the bacteriophage populations resulting from the above experiment and performed a mutation accumulation study.
In A. thaliana, mutation rates have also been estimated by a mutation accumulation study (Ossowski et al. 2009).
Throughout, we have compared our results to those of a recently published mutation accumulation study in Sc. pombe (Farlow et al. 2015).
We also found no significant difference in ΔDE between transitions and transversions in the mutation accumulation study (t = 0.271, P = 0.782), thus contrasting the effect observed in the yeast genome (fig. 2 A ).
One possible explanation is that most of the substitutions analyzed in the mutation accumulation study are in intergenic regions, which are likely to include transposable elements and repeated sequences (Ossowski et al. 2009), which in plants are densely methylated (Finnegan et al. 1998; Zhang et al. 2006; Law and Jacobsen 2010).
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Estimates of mutational variance from mutation accumulation studies are rarely matched with simultaneous estimates of the standing genetic variance in the same traits, measured under the same conditions (Houle et al. 1996).
The mutational biases observed in mutation accumulation studies are consistent with base oxidation being a pre-eminent cause of DNA damage [25].
In the three classical genetic model organisms Drosophila melanogaster, Saccharomyces cerevisiae, and Arabidopsis thaliana, mutation accumulation studies revealed mutational biases pushing their genomes toward high equilibrium A/T contents.
Mutation accumulation studies suggest an average mutation rate of 2.7×10−9 per base pair per generation for the C. elegans genome [25].
This pattern recapitulates that observed in mutation accumulation studies [25], as would be expected for two strains that diverged in the laboratory.
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