Sentence examples for mutation accumulation experiment from inspiring English sources

To explore the mutational spectrum for diverse mutator alleles in a whole-genome context we devised a mutation accumulation experiment.

We performed a mutation accumulation experiment with wild-type and mismatch-repair deficient, mutator lines of the pathogenic bacterium Pseudomonas aeruginosa, and used whole-genome sequencing to reveal the genome-wide rate, spectrum, distribution, leading/lagging bias, and context-dependency of spontaneous mutations.

A single colony from each transformation was selected to begin the mutation accumulation experiment.

Here we present the results from a ∼644-generation-long mutation accumulation experiment in eight replicate MA lines.

The mutation accumulation experiment also included a wild-type control in which MSH2 was intact in the chromosome (genomic WT).

This implies that at least six beneficial mutations were fixed during the mutation accumulation experiment, which corresponds to 0.64% of all mutations that were fixed during the experiment.

One caveat is that bacterial genomes experience a higher neutral deletion rate than neutral insertion rate: Pseudogenes tend to accumulate more small deletions than insertions (Kuo and Ochman 2009a), and mutation accumulation experiments show high genome-wide deletion rates (Nilsson et al. 2005).

Mutation accumulation experiments consider non-adaptive evolution.

Mutation accumulation experiments aim at unraveling the rates and spectrum of spontaneous mutations.

Mutation accumulation experiments can be used to assess the impact of spontaneous mutations on gene regulation [ 182].

Recent high-precision measurements of the deleterious mutation rate in mutation accumulation experiments in Drosophila found U tot ≈ 0.6 deleterious mutations/haploid genome/generation [ 154].