Sentence examples for mutation accumulation assay from inspiring English sources

The theory underlying the mutation accumulation assay is that all mutations other than lethal mutations accumulate as if neutral.

The mutation accumulation assay provides an alternative to reporter assays.

In this study, we calculated the mutation rates across the entire genome by using haploid wild-type and mismatch repair defective cells in a mutation accumulation assay over ~170 generations.

In a mutation accumulation assay, the population is propagated through recurrent single-cell bottlenecks, thus mitigating the effect of selection and allowing mutations (other than lethal mutations) to accumulate as if they were neutral.

Because the mutation accumulation assay queries many types of mutation events and contexts simultaneously, it not only produces a more accurate estimate of the per-genome per-generation mutation rate, but also allows one to determine how the mutation rate is influenced by sequence-specific features and genomic context.

We performed mutation accumulation assays and next generation sequencing on 19 strains, including 16 missensesense variants implicated in Lynch cancer syndrome.

In this study, we have shown that the combination of mutation accumulation assays and next-generation sequencing is a powerful general method for revealing the genome-wide rate, spectra, and distribution of mutations in lines harboring Lynch Syndrome associated variants of the mismatch repair protein, Msh2.

The performance of cell cycle control strategies in terms of replication-dependent mutation accumulation can thus be assayed by the balance in the cell pedigree trees that they produce.

Phenotypic assays of fitness in mutation accumulation lines suggest that C. briggsae might experience a higher mutation rate than C. elegans [ 59], although this observation has not yet been confirmed with direct mutation detection.

Between-line variability in the rate of mutation accumulation.

Blokzijl, F. et al. Tissue-specific mutation accumulation in human adult stem cells during life.