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Mutant mice expressing Cav1.3 gain-of-function mutations are required to confirm this hypothesis.
Results indicate that mutant mice expressing lower HO-1 had fewer lung metastases compared to mice expressing normal HO-1.
We have previously shown that mild ER stress was detected in chondrocytes from mutant mice expressing Comp T585M.
Double PSAPP mutant mice expressing mutant presenilin 1 (PS1) and APPsw also show age-dependent Aβ deposition, but also no neuronal loss (Takeuchi et al., 2000).
The mutant mice expressing no GM1 showed a significant increase of Aβ accumulation in vascular tissues and formation of dysphonic-form amyloid angiopathy in the brain.
Resolution of this issue, as well as direct demonstration that NRP2 is required for SEMA3s action on lymphatic sprouting in vivo, will require Nrp2 mutant mice expressing Nrp2 with a mutation which selectively abolishes SEMA3s-NRP2 binding.
Similar(53)
Mutant mice expressed both wild-type and mutant decorin.
Taken together, these findings indicate that astrocytes in the mutant mice express an active NOS isoform.
Interestingly, the mutant mice expressed lower basal levels of Slfn4 in BMM.
Homozygous mutant mice express normal Scarb1 mRNA levels and are fertile.
Altogether, these data demonstrate that ΔCS mutant mice express increased levels of mFasL and no detectable sFasL.
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