Sentence examples for multiple signaling processes from inspiring English sources

Moreover, multiple signaling processes, such as those acting through the Ca2+ and PKC/MAPK pathways, were rapidly activated in target cells through ROS production.

Moreover, tankyrase, GSK3, and γ-secretase functions are not restricted to Wnt or Notch pathway regulation, and inhibitors of these enzymatic activities will likely perturb multiple signaling processes in vivo.

It has recently been shown that under conditions of systemic insulin resistance the heart remains insulin sensitive [ 25]; therefore, chronic stimulation of multiple signaling processes in the myocardium by leptin and insulin may result in cardiac pathology.

In addition, we and others have suggested that multiple signaling processes, such as those acting through the Ca2+ and PKC pathways, were rapidly activated in target cells through ROS and that these pathways are linked to bacterial stratagems to modulate the host signaling pathway.

Regulation of the lens cytoskeleton has also been linked to multiple signaling processes involving cadherins (Leonard et al., 2013), integrins (Basu et al., 2014a), IGF1R/NF-κB (Basu et al., 2012), PI3K (Weber and Menko, 2006b) and the mitochondrial cell death pathway (Weber and Menko, 2005; Basu et al., 2012).

When multiple downstream signaling processes (v26, v28, v44, and v52) are targeted for inhibition, the ERK-PP signal response becomes much more sensitive to the levels of inhibition.

Mitochondria are the essential organelles for energy supply of cells and can respond to multiple physiological stresses via signaling processes, cell growth and differentiation events.

Since our prior data indicate that AQP2 is required for the VP-induced exocytosis of ssYFP in LLC-PK1 cells, it is likely that, as discussed earlier, AQP2/actin association and signaling processes have multiple cellular effects on the AQP2 recycling pathway.

MI involves the activation of multiple stress signalling processes, such as oxidative stress, that generate reactive oxygen species (ROS), leading to the expression of inflammatory mediators, including TNF-α, which induces Iκ-Bα degradation and NF-κβ phosphorylation.

As a result, the mammalian cell death machinery is intertwined with multiple cellular signaling processes that are part of normal cellular physiological signaling processes, providing backups and flexible signaling mechanisms to cell death signaling.

A mature miRNA regulates the post transcriptional gene expression by targeting certain mRNAs, subsequent to which, it modulates multiple signaling pathways, biological processes and patho-physiologies.