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Molecular chaperones help hundreds of signaling molecules to keep their activation-competent state, and regulate various signaling processes ranging from signaling at the plasma membrane to transcription.
While kinases are involved in various signaling processes, they are still structurally very similar when it comes to their ATP binding sites, which are highly conserved [14, 15].
In addition, various signaling processes, including gene expression regulation and cell development and differentiation, were also significantly enriched.
In addition to the substrate protein, ubiquitin becomes ligated to itself through different primary amino groups in ubiquitin, and this polyubiquitination process codes the fate of the substrate proteins (e.g., degradation, membrane trafficking, and various signaling processes).
The serine/threonine kinase protein kinase D1 (PKD) is a regulator of trafficking from the trans-Golgi network (TGN), and also of various signaling processes such as proliferation, motility, and cell death.
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Furthermore, aberrant activation of various signalling processes and increased apoptosis has been observed (Le Dour et al., 2011; Kumar and Boriek, 2003).
The technique should have wide applicability to various cell types and diverse signaling processes.
Past studies have established that K48-linked chains are responsible for proteasomal degradation and that K63-linked chains are involved in various cell signaling processes.
Maintenance of redox balance in mitochondria is crucial for normal cell physiology and depends on the cross-talk between the various redox signaling processes and the mitochondrial oxidative folding pathway.
It is well known that K48-linked ubiquitin chains are responsible for proteasomal degradation and that K63-linked chains are involved in various cell signaling processes, though the roles of other atypical ubiquitin linkages through M1, K6, K11, K27, K29 or K33 or mixed linkages within the same chain remain unclear (Kulathu and Komander, 2012).
Overexpression of PTPRH disrupted the actin-based cytoskeleton and inhibited various integrin-promoted signaling processes [76].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com