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Here, we asked whether multiple posttranslational modifications could be simultaneously controlled and matched to rationally generate new peptide derivatives.
Recent studies suggest that tau, upon alternative mRNA splicing and multiple posttranslational modifications, may participate in the regulations of intracellular signal transduction, development and viability of the neurons.
In vertebrates, Drp1 is subjected to multiple posttranslational modifications, including phosphorylation, ubiquitination and sumoylation [26].
IF proteins can undergo multiple posttranslational modifications.
Many proteins carry multiple posttranslational modifications.
Histone tails harbour multiple posttranslational modifications.
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Multiple posttranslational oxidative modifications occur at Cys 294 in the α-subunit, providing evidence for the role of this residue as a redox sensor [43].
Additionally, multiple different posttranslational modifications have been identified in p53.
Besides ubiquitination, multiple frequent posttranslational modifications occur at lysine residues, such as SUMOylation and acetylation.
Although previously viewed as relatively inert structural proteins, histones are now recognized to be the targets of multiple dynamic posttranslational modifications, particularly on their C-terminal tails.
Additionally, the isotopic signature imparted by the dibromide tag was detectable on a 12-kDa protein, suggesting applications in identifying large peptide fragments, such as those containing multiple or large posttranslational modifications (e.g., glycosylation).
Related(11)
various posttranslational modifications
numerous posttranslational modifications
several posttranslational modifications
many posttranslational modifications
multiple genetic modifications
multiple epigenetic modifications
multiple different modifications
multiple biochemical modifications
multiple covalent modifications
multiple structural modifications
multiple posttranslational events
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