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The reported cross-coupling methodology is orthogonal to many reported conjugation methods and supplements these to enable the introduction of multiple different modifications.
In addition, and very importantly, sequential ligations allow multiple different modifications to be placed at distinct sites along the polypeptide chain.
Similar(58)
Additionally, multiple different posttranslational modifications have been identified in p53.
Since there were multiple ways in which we could combine the different modifications, it became necessary to try to reduce the number of possible network realizations, as outlined in Step III.
For example, we observe a MC on chromosome 2 (HF087) in a genomic region bearing a histone modification pattern characteristic of insulators in multiple different normal cell types, but the pattern changes to that of an enhancer in hepatocellular carcinoma.
Multiple modification variants were detected on 6 sites (14.6%), with a maximum of four different modifications per site.
"I tried a dozen different modifications that were rejected.
"Infrastructure located on multiple continents, in multiple different geographic regions".
They have multiple different products.
Different modifications worked better with different proteins.
Hundreds of different modifications exist.
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