Sentence examples for numerous posttranslational modifications from inspiring English sources

The in vitro studies on the BCRP efflux system have demonstrated that some cell lines displayed erratic efflux profiles of doxorubicin and rhodamine 123, and these observations were attributable to 482nd position in the amino acid sequence consisting of arginine, glycine or threonine residues which are susceptible to numerous posttranslational modifications [18 20].

The number and position of the detected spots reflect numerous posttranslational modifications of vimentin such as phosphorylation and citrullination, which have been previously described for this protein [44], [45], [46].

HSF1 activity is modulated not only by interactions with chaperones but also by numerous posttranslational modifications including phosphorylation, acetylation, and sumoylation [ 56].

Based on the comprehensive analysis of these datasets by a wide array of modern bioinformatics tools it was concluded that disordered regions of PCD-related proteins are involved in a multitude of biological functions and interactions with various partners, possess numerous posttranslational modification sites, and have specific evolutionary patterns (Peng et al. 2013).

Furthermore, while ANXA1 can undergo numerous distinct posttranslational modifications which can alter function and are distinguishable by changes in isoelectric point [ 14], the specific identities of the alterations are beyond the scope of the present studies.

However, this expression system does not encode for the numerous other posttranslational modifications, such as hydroxylation of lysines and glycosylation of the hydroxylysines, that are part of collagen's higher-order assembly pathway and affect its stability and physiological function [ 6, 13].

This disordered C-tail, with its set of MoRFs, conserved eukaryotic linear motifs, and numerous sites of posttranslational modifications, plays a crucial role in a multitude of PTEN-based protein-protein interactions.

The activity of PKM2 can be regulated by numerous allosteric effectors and posttranslational modifications (PTMs) that could change its conformation.

Indeed, actin's posttranslational modifications are numerous.

Radical SAM chemistry plays critical roles in numerous biosynthetic pathways including antibiotic production, posttranslational modifications, synthesis of protein cofactors, and catalyzing the synthesis of the nonprotein ligands that impart chemical reactivity to some of the most complex biological metal clusters known.

Numerous signaling pathways converge to affect the levels and posttranslational modifications of Bcl-2 family proteins.