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In oxidative stress p53 protein is activated through multiple posttranslational events including phosphorylation [ 46].
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Thus, although we have confirmed an upregulation of select metabolic process genes and a down-regulation of extracellular matrix genes at the mRNA level and even at the protein level, multiple additional posttranscriptional and posttranslational events may be required to fully implicate these factors in the acute kidney injury following CPB.
Phosphorylation and glycosylation are important posttranslational events in the biosynthesis of proteins.
Here, we asked whether multiple posttranslational modifications could be simultaneously controlled and matched to rationally generate new peptide derivatives.
Recent studies suggest that tau, upon alternative mRNA splicing and multiple posttranslational modifications, may participate in the regulations of intracellular signal transduction, development and viability of the neurons.
In vertebrates, Drp1 is subjected to multiple posttranslational modifications, including phosphorylation, ubiquitination and sumoylation [26].
These posttranslational events could affect tyrosine-dependent covalent dimerization, zinc transport, and cell response to metal challenges.
To i) analyze posttranslational interactions in MeJA and SA signaling pathways and ii) to test if kinome profiling can be used to predict biologically relevant posttranslational events in plant signaling and behavior at the whole plant level, we profiled the kinome of MeJA- and SA-treated plants.
Here, the effects of MeJA and SA on the Arabidopsis thaliana kinome were monitored using PepChip arrays containing kinase substrate peptides to analyze posttranslational interactions in MeJA and SA signaling pathways and to test if kinome profiling can provide leads to predict posttranslational events in plant signaling.
IF proteins can undergo multiple posttranslational modifications.
Many proteins carry multiple posttranslational modifications.
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