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The fact that multiple PKC isoforms play a role in PMA-induced HB-EGF shedding in HT1080 cells is in line with previous findings, indicating that PMA-induced shedding of EGFR-ligands implicates multiple pathways, acting at the level of both protease and substrate [34], [35], [36].
There are multiple pathways acting across time, and variables with roles as both confounders and mediators.
As a consequence of the multiple pathways acting in concert, the cell-cycle defects increase in severity upon disruption of two or more parallel pathways.
Second, computational modeling will allow us to predict the cumulative effect of multiple pathways acting simultaneously and feeding back on one another [ 206].
These type of proteins are associated with signal transduction mediation in multiple pathways, acting like the hormones cytokinin and ethylene [ 27].
Metastasis is the result of multiple pathways acting in concert to provide tumour cells with the capacity to migrate, to gain access to the bloodstream or lymphatic vessels, and to ultimately home to distant sites.
Similar(54)
These divergent functions of FoxO proteins are regulated by multiple signaling pathways acting at both the transcriptional and posttranslational levels [47], [54], [107].
Altogether, our data suggest that multiple signaling pathways, acting in parallel and modulating specific actin regulatory proteins, play a role in integrating responses during BMP-induced actin reorganization and cell migration.
Their turnover and localization most likely follows the changes triggered by the multiple signalling pathways acting on pollen tube secretion.
Food entrainment may involve multiple parallel entrainment pathways, acting on a fully distributed, non-hierarchical system of circadian oscillators in local circuits, each responsible for generating food-entrained rhythms in tissue specific functions.
It is probable that associations between the various constituents of PM and health effects are the result of multiple, complex and interdependent mechanistic pathways acting on different physiological mechanisms.
Related(20)
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