Sentence examples for multiple mutations acting from inspiring English sources

In view of the polygenic influence on the complex traits, the variations in abdominal fatness are probably due to variations in several biological pathways, impacted by multiple mutations acting separately or in interaction.

While a large number of mutations acting in one direction (for example, all mutations act to increase a trait value) indicates consistent selective pressure [ 3], temporal or spatial variation in selective pressure will not consistently favor mutations acting in one direction, and will thus result in a large number of mutations acting in opposite directions.

Thus bad mutations acting at young age can hardly spread in the population due to Darwinian selection pressure; for mutations acting at old age this pressure is much weaker, and these mutations can spread widely.

This evidence strongly suggests that MA lines that are significantly different from the ancestor for multiple fitness components carry multiple, independently acting mutations.

DOI: http://dx.doi.org/10.7554/eLife.01322.006 Combining multiple mutations in the Founder Δe14 background allowed us to assess whether mutations were acting additively or affected single pathways.

In a large population with a high mutation rate, however, multiple mutations co-occur in the population and the change in frequency of one mutation also depends on selection acting at linked sites.

"We already have the technical capabilities to assess men for multiple mutations at once, so all that remains is for us to do further work to prove that picking up dangerous mutations early can save lives.

"There are probably genetic links in other diseases, but they probably involve not a single gene but multiple mutations," she said.

Many human diseases are caused by multiple mutations.

This technology also has the capability to correct multiple mutations simultaneously, which will be crucial to curing diseases that arise by more than one genetic mutation.

Chronocoordinate multiple mutations that span multiple kilobases [9].