GBC being a multifactorial and multistep disease, there may be a complex interaction between multiple risk alleles acting in a stronger manner in a combination rather than individually.
Such findings highlight the complex nature of prostate cancer susceptibility, which is likely due to multiple susceptibility alleles acting in tandem with environmental components.
The genotype more plausibly consists of multiple co-existing susceptibility alleles acting through heightened susceptibility to hormones and/or defective tumour suppression.
We propose that Sk/Sp aneuploids are more resistant to poisons produced by meiotic drive alleles acting in hybrids.
Additionally, only weak evidence was found for signatures of balancing selection acting to maintain multiple alleles at intermediate frequencies over prolonged periods of time.
The Multiple Alleles at the MZ Locus.
Hence the C-KO procedure greatly facilitates simultaneous inactivation of multiple alleles.
Van Eck, H. J. et al. Multiple alleles for tuber shape in diploid potato detected by qualitative and quantitative genetic analysis using RFLPs.
Alleles may occur in pairs, or there may be multiple alleles affecting the expression (phenotype) of a particular trait.
The QTL effects were consistently higher when the extra alleles were designated as Pokkali (data not shown), suggesting that the "non-parental" alleles may actually represent multiple alleles from heterozygous loci of the original Pokkali parent.
