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Taken together, the results of the network analysis suggest that myogenesis is regulated by a complicated network, mediated by multiple miRNAs acting through the same target gene, and/or single miRNAs targeting multiple genes.
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After using the AgriGO toolkit to perform GO analysis of mRNAs that could be targeted by the same miRNAs acting on lincRNAs [ 66], we found that lincRNAs acting as miRNA decoys were involved in multiple biological processes, participated in the formation of many cellular components, and influenced the activities of molecular functions (Fig. 9, Additional file 15).
In this review, we summarize recent findings on miRNAs acting as essential regulators of ESCs and somatic cell reprogramming based on these categories.
Some miRNAs, acting as oncogenes, promote tumour aggravation by downregulation of tumour suppressors (Hammond, 2007).
Indeed, cases of miRNAs acting on genes involved in particular functional processes have been described [ 43- 45].
This gave a set of n = 360 different miRNAs acting on n = 1472 different genes.
It contains 542 antiviral miRNAs acting against 26 different viruses (Supplementary Table S3).
Previous reports showed that lncRNA communicates with mRNAs, pseudogenes, circular RNAs and miRNAs, acting as endogenous miRNA sponges, ceRNAs or a target of miRNA.
These studies comprised global approaches to determine multiple miRNAs or measurement of single miRNA candidates.
MiRNA families comprise multiple miRNAs exhibiting primary sequence similarity to a specific seed sequence.
Our MB-based miRNA imaging system may serve as a new imaging probe for monitoring multiple miRNAs during various cellular or disease processes associated with miRNAs.
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