Sentence examples for multiple mutations with from inspiring English sources

The additional observation that various phenotypes must be acquired suggests multiple mutations with no clonal expansion or a mutator mutation (a mutation that generates more mutations) coupled with clonal expansion [ 41].

Briefly, T400, T404 and S408 were mutated to Ala or Glu (single or multiple mutations) with the Change-IT™ Multiple Mutation Site Directed Mutagenesis Kit (USB).

However, potential issues of using domain-centric ontologies arise when a common domain harbors multiple mutations with distinct and uniquely expressed phenotypes.

It remains largely unknown if such decay would stem from multiple mutations with small effects or rather involve few loci with major phenotypic effects.

It is largely unknown if trait decay typically stems from multiple mutations with small effects, or rather has a simple genetic architecture involving few loci with major phenotypic effects (Jeffery, 2009; Lahti et al., 2009).

Cytoskeletal abnormalities that included dystrophic neurites, decreased dendritic areas, and decreased spine numbers have been described in hippocampal neurons of mice that carried an APP transgene with multiple mutations associated with familial AD[29].

Again, the number of ARV regimens prescribed was positively correlated with the chance of having multiple mutations associated with resistance.

The higher the number of ARV regimens already used, the higher the chance of having multiple mutations associated with resistance to zidovudine (ZDV), stavudine (d4T), and tenofovir (TDF) (p = 0.011, 0.010, and <0.001, resp .. Half of the patients (50.1%) were using NNRTIs at the time of genotyping and most of those (83.6%) were on efavirenz (EFV) (Table 1).

The role of adding MC to rechallenge of IM in heavily pretreated patients have to be studied in an appropriate randomised trial enrolling selected cases (e.g., GIST with multiple mutations or GIST with D842V mutation).

The study showed that clustering patients by probability score across multiple mutations identified groups with significantly divergent prognoses.

43, 44 After Goldstein and Brown 6 identified LDLr dysfunction as cause of FH, multiple mutations were associated with this disease.