For example, the most frequent mutation with a strong founder effect p.Gly2019Ser was reported worldwide with an average frequency of 1% in PD patients [ Paisan-Ruiz, 2009].
Taking T16519C as the most frequent mutation with 209 occurrences according to Ref. [27], we derived fluctuation rates for all other mutations following the formula r = r(T16519C) × n/209.
We then specifically examined correlations between our lncRNAs and expression of EZH2, a transcriptional repressor, implicated in tumorgenesis in DLBCL due to frequent mutations and with known interactions with lncRNAs [ 22, 23].
Y181C and T215Y were the most frequent mutations associated with interpretation differences.
For MDR-TB, the most frequent mutations associated with RIF and INH resistance can be assessed by sequencing, line-probe assays or other methods [ 28, 29].
In the phylogenetic convergence test mentioned above, a relatedness tree, constructed using the whole genome data is used to identify genes that accumulate frequent mutations synchronous with the acquisition of the phenotype of interest.
Thymidine analogue mutations, including T215 revertants, remained the most frequent mutations associated with nucleos(t)ide reverse transcriptase inhibitors, despite a considerable fall in stavudine and zidovudine use between 2002 and 2009 (from 29.4% of drug regimens in 2002 to 0.8% in 2009, from 47.9% to 8.8%, respectively).
DNA vaccines are a new-generation vaccines that elicit an immunological response against a wide-variety of antigens with frequent mutations.
High-grade tumors harbored genetic alterations of TP53 and CDKN2A, frequent mutations of ATRX associated with Alternative Lengthening of Telomere, and were enriched in genetic alterations of transcription/chromatin regulation and PI3 kinase pathways.
Mismatch repair deficiency has previously been associated with frequent mutations in the β2-m gene (B2M [ 24, 32- 35].
