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Exact(12)
This region is mosaic with areas of high and low GC contents, suggesting that it arose from multiple genetic events.
However, most cancers are caused by multiple genetic events making it difficult to determine which oncogenes or combination of oncogenes will be the most effective targets for their treatment.
Breast cancer arises from multiple genetic events that together contribute to the established, irreversible malignant phenotype.
It is well accepted that the accumulation of multiple genetic events in different genes and molecular pathways is the main cause of OSCC evolution [ 3, 32].
We have generated a simple model in an attempt to explain multiple genetic events and complex physiological pathways and recognise the limitations of attempting to do this.
Indeed, the probability of genetic events over time should be expected either to remain constant (if only a single genetic event is required) or to increase with time (if the accumulation of multiple genetic events is required).
Similar(48)
Equal numbers of shared genes from the distributed set were shared by one or multiple plasmids, indicating that both single and multiple genetic exchange events among plasmids and chromosomes occurred during evolutionary history.
For example, 1) compared to the use of the well-tested and reliably-used recombinase systems, additional development and testing of CRISPR/Cas9 to generate multiple genetic insertion events will be necessary to ensure widespread use and application.
It was recently shown in M. smegmatis that distributive conjugal transfer could induce multiple genetic transfer events in a single step, and the authors of that study proposed that this mechanism created the genome mosaicism observed among M. canettii (19 ).
Therefore, multiple genetic recombination events are probably involved in the evolution of both IbA10G2 and IaA28R4 and are likely responsible for the observed emergence of the same virulent gp60 subtypes in different geographical locations in response to selection pressure [ 46].
Multiple genetic and epigenetic events characterize tumor progression and define the identity of the tumors.
Related(20)
multiple transgenic events
many genetic events
multiple genomic events
multiple biological events
numerous genetic events
several genetic events
multiple reproductive events
various genetic events
multiple genetic loci
multiple genetic variants
multiple genetic components
multiple genetic models
multiple genetic screens
multiple genetic differences
multiple genetic factors
multiple genetic traits
multiple genetic circuits
multiple genetic perturbations
multiple queer events
multiple genetic conditions
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